Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9

Methods Enzymol. 1996:272:139-45. doi: 10.1016/s0076-6879(96)72017-7.

Authors

J O Miners¹, D J Birkett

Affiliation

¹ Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, South Australia.

PMID: 8791771
DOI: 10.1016/s0076-6879(96)72017-7

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aryl Hydrocarbon Hydroxylases*
Chlorpropamide / analysis
Chlorpropamide / metabolism
Chromatography, High Pressure Liquid
Cytochrome P-450 Enzyme System / metabolism*
Humans
Hypoglycemic Agents / metabolism
In Vitro Techniques
Microsomes, Liver / enzymology
Molecular Probes
Reproducibility of Results
Steroid 16-alpha-Hydroxylase*
Steroid Hydroxylases / metabolism*
Substrate Specificity
Tolbutamide / analogs & derivatives
Tolbutamide / analysis
Tolbutamide / metabolism*

Substances

Hypoglycemic Agents
Molecular Probes
hydroxymethyltolbutamide
Cytochrome P-450 Enzyme System
Tolbutamide
Steroid Hydroxylases
Aryl Hydrocarbon Hydroxylases
Steroid 16-alpha-Hydroxylase
Chlorpropamide