Assays of CYP2C8- and CYP3A4-mediated metabolism of taxol in vivo and in vitro

Methods Enzymol. 1996;272:145-51. doi: 10.1016/s0076-6879(96)72018-9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antineoplastic Agents, Phytogenic / analysis
  • Antineoplastic Agents, Phytogenic / blood
  • Antineoplastic Agents, Phytogenic / metabolism*
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / metabolism*
  • Feces / chemistry
  • Humans
  • In Vitro Techniques
  • Microsomes, Liver / enzymology
  • Mixed Function Oxygenases / metabolism*
  • Paclitaxel / analysis
  • Paclitaxel / blood
  • Paclitaxel / metabolism*

Substances

  • Antineoplastic Agents, Phytogenic
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • CYP3A protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • Paclitaxel