Montiporic acids A and B, cytotoxic and antimicrobial polyacetylene carboxylic acids from eggs of the scleractinian coral Montipora digitata

J Nat Prod. 1996 Aug;59(8):796-7. doi: 10.1021/np9604036.

Abstract

Two new polyacetylene carboxylic acids, montiporic acids A (1) and B (2), have been isolated from the eggs of the scleractinian coral Montipora digitata and their structures elucidated on the basis of spectroscopic data. They exhibited antimicrobial activity against Escherichia coli and cytotoxicity against P-388 murine leukemia cells.

MeSH terms

  • Acetates / chemistry
  • Acetates / isolation & purification
  • Acetates / pharmacology*
  • Acetylene / analogs & derivatives*
  • Acetylene / chemistry
  • Acetylene / isolation & purification
  • Acetylene / pharmacology
  • Alkynes
  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / therapeutic use*
  • Carboxylic Acids
  • Cell Division / drug effects
  • Cnidaria / chemistry*
  • Escherichia coli / drug effects*
  • Lethal Dose 50
  • Leukemia P388 / drug therapy*
  • Leukemia P388 / pathology
  • Magnetic Resonance Spectroscopy
  • Mice
  • Ovum
  • Spectrometry, Mass, Fast Atom Bombardment
  • Tumor Cells, Cultured

Substances

  • Acetates
  • Alkynes
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Carboxylic Acids
  • montiporic acid A
  • montiporic acid B
  • Acetylene