Active constituents against HIV-1 protease from Garcinia mangostana

Planta Med. 1996 Aug;62(4):381-2. doi: 10.1055/s-2006-957916.

Abstract

The ethanol extract of Garcinia mangostana L. (Guttiferae) showed potent inhibitory activity against HIV-1 protease. The activity-guided purification of the extract resulted in the isolation of two active, known compounds. The chemical structures of the isolated compounds were established by spectroscopic analyses as mangostin (IC50 = 5.12 +/- 0.41 microM) and gamma-mangostin (IC50 = 4.81 +/- 0.32 microM). The type of inhibition by both compounds is noncompetitive.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • HIV Protease / metabolism*
  • HIV Protease Inhibitors / chemistry
  • HIV Protease Inhibitors / isolation & purification*
  • HIV Protease Inhibitors / pharmacology
  • HIV-1 / enzymology
  • Kinetics
  • Molecular Sequence Data
  • Molecular Structure
  • Oligopeptides / metabolism
  • Plant Extracts / pharmacology
  • Plants, Medicinal*
  • Substrate Specificity
  • Xanthenes / chemistry
  • Xanthenes / isolation & purification*
  • Xanthenes / pharmacology
  • Xanthones*

Substances

  • HIV Protease Inhibitors
  • Oligopeptides
  • Plant Extracts
  • Xanthenes
  • Xanthones
  • gamma-mangostin
  • HIV Protease
  • mangostin