Selective role for trkB neurotrophin receptors in rapid modulation of hippocampal synaptic transmission

Brain Res Mol Brain Res. 1996 Jun;38(2):300-3. doi: 10.1016/0169-328x(96)00025-3.


Neurotrophins regulate neuronal survival and phenotypic differentiation. Recent evidence also suggests a role in the modulation of synaptic activity. Using neuronal cell cultures from embryonic hippocampus, we previously found that application of brain-derived neurotrophic factor rapidly enhanced synaptic transmission. We now report that application of neurotrophin-4, another ligand for the trkB neurotrophin receptor, was equally effective in enhancing synaptic currents. In contrast, nerve growth factor, neurotrophin-3, basic fibroblast growth factor and epidermal growth factor did not share this action. Our results suggest that activation of trkB receptors plays a selective role in the regulation of synaptic efficacy in the hippocampus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cells, Cultured
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Neurons / physiology*
  • Patch-Clamp Techniques
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Ciliary Neurotrophic Factor
  • Receptors, Nerve Growth Factor / physiology*
  • Synaptic Transmission / physiology*
  • Time Factors


  • Receptor, Ciliary Neurotrophic Factor
  • Receptors, Nerve Growth Factor