Abstract
Mitochondria have their own DNA which is maternally inherited. Mitochondrial DNA (mtDNA) diseases are extremely variable because of the genetics of mtDNA and the unique pathogenesis of these disorders. This makes predicting the prognosis and transmission of these disorders difficult.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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DNA, Mitochondrial / genetics*
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Gene Rearrangement / genetics
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Humans
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Mitochondrial Myopathies / diagnosis
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Mitochondrial Myopathies / genetics*
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Mitochondrial Myopathies / therapy
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Point Mutation / genetics
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Prenatal Diagnosis
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Prognosis