Wegener's granulomatosis overlapped with Takayasu arteritis

Clin Rheumatol. 1996 May;15(3):303-6. doi: 10.1007/BF02229714.


A 27-year-old woman presented with destructive scleritis of the left eye with subcutaneous haemorrhage and swelling of the lower eyelid. She had experienced recurrent nasal bleeding for the last six years, and chronic sinusitis resulting in the destruction of the nasal septum and left maxillary sinus. Nasal mucosal biopsies demonstrated granuloma formation with no evidence of vasculitis. The level of serum cytoplasmic anti-neutrophil cytoplasm antibody (c-ANCA) was significantly increased. Furthermore, multiple sites of complete occlusions were detected in the left subclavian and common carotid arteries by subtraction angiography and MRI. We describe a case of Wegener's granulomatosis overlapped with Takayasu arteritis, which, to our knowledge, has not been previously reported.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angiography, Digital Subtraction
  • Antibodies, Antineutrophil Cytoplasmic / analysis
  • Aorta, Thoracic / diagnostic imaging
  • Aorta, Thoracic / pathology
  • Female
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / diagnostic imaging
  • Granulomatosis with Polyangiitis / immunology
  • Humans
  • Magnetic Resonance Imaging
  • Orbit / diagnostic imaging
  • Pulmonary Artery / diagnostic imaging
  • Respiratory Tract Diseases / complications*
  • Respiratory Tract Diseases / diagnostic imaging
  • Takayasu Arteritis / complications*
  • Takayasu Arteritis / diagnosis
  • Tomography, X-Ray Computed


  • Antibodies, Antineutrophil Cytoplasmic