Intracellular signalling: putting JAKs on the kinase MAP

Curr Biol. 1996 Jun 1;6(6):668-71. doi: 10.1016/s0960-9822(09)00445-x.

Abstract

Tyrosine kinases of the JAK family are required for activation of both STAT transcription factors and the ERK/MAP kinase pathway, suggesting a mechanism for the optimization of gene induction via the coordinate activation of multiple transcription factors.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Humans
  • Janus Kinase 3
  • Protein-Serine-Threonine Kinases / metabolism
  • Protein-Tyrosine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-raf
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism
  • Transcription, Genetic
  • ras Proteins / metabolism

Substances

  • Proto-Oncogene Proteins
  • Transcription Factors
  • Protein-Tyrosine Kinases
  • JAK3 protein, human
  • Janus Kinase 3
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-raf
  • Calcium-Calmodulin-Dependent Protein Kinases
  • ras Proteins