Lymphocyte migration into tissue: the paradigm derived from CD4 subsets

Curr Opin Immunol. 1996 Jun;8(3):312-20. doi: 10.1016/s0952-7915(96)80118-x.


The appropriate recirculation and migration of naive, effector and memory T cells into inflamed tissue are precisely controlled by adhesive interactions with vascular endothelium. Analyses of CD4 lymphocytes have indicated that naive and antigen-experienced cells exhibit distinctive patterns of homing and recirculation, and that subsets of cells preferentially localize in different anatomical locations as a consequence of previous antigen exposure and differences in adhesion receptor usage.

Publication types

  • Review

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Movement / immunology*
  • Humans
  • Models, Immunological*