Role of Fas-mediated cell death in the regulation of immune responses

Curr Opin Immunol. 1996 Jun;8(3):355-61. doi: 10.1016/s0952-7915(96)80125-7.


Interaction of the cell-surface molecule Fas (CD95 APO-1) with its specific ligand triggers apoptotic death of T and B lymphocytes. This pathway is important for eliminating self-reactive lymphocytes and thus preventing autoimmunity. Fas is also involved in controlling injurious lymphocyte reactions in immunologically 'privileged' tissues, and may provide a strategy for reducing graft rejection.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • Cell Death / immunology*
  • Humans
  • Lymphocyte Activation
  • T-Lymphocytes / immunology*
  • fas Receptor / physiology*


  • fas Receptor