T-cell recognition of non-peptide antigens

Curr Opin Immunol. 1996 Aug;8(4):510-6. doi: 10.1016/s0952-7915(96)80039-2.


Studies of two distinct human T-cell systems have provided the exciting finding that T cells are able to recognize non-peptide antigens: gammadelta T cells have been shown to recognize isopentenyl pyrophosphate and related structures and human CD1 has been shown to present microbial lipids and lipoglycans such as mycolic acids and lipoarabinomannan to T cells. T-cell responses to these non-peptide antigens should provide a strategic target for immunologic intervention in infectious disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigen Presentation*
  • Antigens, Bacterial / chemistry*
  • Antigens, Bacterial / immunology*
  • Carbohydrate Sequence
  • Humans
  • Lipopolysaccharides / immunology*
  • Molecular Sequence Data
  • T-Lymphocytes / immunology*


  • Antigens, Bacterial
  • Lipopolysaccharides