Pax proteins and eye development

Curr Opin Neurobiol. 1996 Feb;6(1):49-56. doi: 10.1016/s0959-4388(96)80008-0.


Homologous members of the Pax gene family are required for eye development in Drosophila and vertebrates. Despite superficial similarities in the phenotypes of vertebrates with mutations in pax-6 and Drosophila eyeless mutants, it remains uncertain whether the two proteins encoded by these genes have comparable functions. The genetic cascade triggered by eyeless leads to eye formation, whereas pax-6 is not necessary for optic vesicle formation, but is required at other stages of eye development. A second vertebrate Pax gene, pax-2, is also required during eye development and appears to play a role during closure of the choroid fissure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Eye / growth & development*
  • Genes / genetics*
  • Humans
  • Models, Neurological
  • Mutation
  • Phenotype
  • Transcription Factors / genetics*


  • Transcription Factors