Paired recording is a powerful and versatile tool to examine communication between and within neurones. This technique has provided new insights in studies of synaptic function and plasticity, of neuronal integration, and of the decoding of neuronal circuits. Recent studies using dual recordings in combination with morphology have successfully determined the number of transmitter release sites between synaptically connected neurones. Important progress in understanding the dynamics of signal transmission within individual cells has been made possible using infra-red microscopy, which permits dual recordings from visualized somatic and dendritic sites on a single neurone.