Calcium permeability of glutamate-gated channels in the central nervous system

Curr Opin Neurobiol. 1996 Jun;6(3):311-7. doi: 10.1016/s0959-4388(96)80113-9.


Molecular cloning of ionotropic glutamate receptors and the development of new measurement techniques have significantly advanced our understanding of the molecular mechanisms controlling ligand-mediated entry of Ca2+ into neurons of the mammalian CNS. Recent studies have demonstrated that various types of glutamate receptors expressed in different nerve cells are permeable to Ca2+ to variable extents, depending on the structural peculiarities of the subunits and their composition in a particular cell. This diversity provides a regulable pathway for Ca2+ entry during synaptic transmission. The fractional contribution of this Ca2+ to the total synaptic current might be a substantial means of elevating the intracellular Ca2+ concentration over a wide temporal range.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Central Nervous System / metabolism*
  • Glutamic Acid / pharmacology*
  • Ion Channel Gating*
  • Ion Channels / drug effects*
  • Ion Channels / metabolism*
  • Permeability


  • Ion Channels
  • Glutamic Acid
  • Calcium