Cytochrome c oxidase

Curr Opin Struct Biol. 1996 Aug;6(4):460-6. doi: 10.1016/s0959-440x(96)80110-2.


Within the past year, the structures of the cytochrome c oxidase from the soil bacterium Paracoccus denitrificans and of the metal centers of the cytochrome c oxidase from bovine heart mitochondria, both determined at 2.8 A resolution by X-ray crystallography, have been reported. The structures form a basis for understanding the mechanism of this redox-coupled transmembrane proton pump, which is the key component of the respiratory chain of most aerobic organisms.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Copper / chemistry
  • Electron Transport Complex IV / chemistry*
  • Models, Molecular
  • Paracoccus denitrificans / enzymology*
  • Protein Conformation


  • Copper
  • Electron Transport Complex IV