Porins: General to Specific, Native to Engineered Passive Pores

Curr Opin Struct Biol. 1996 Aug;6(4):485-90. doi: 10.1016/s0959-440x(96)80113-8.

Abstract

Several porins from bacterial outer membranes have been crystallized and analyzed by X-ray diffraction, yielding a consistent picture of these membrane-channel proteins. The structures of general and specific channels are in agreement with electrophysiological, diffusional and biochemical data, and provide a starting point for the engineering of other passive membrane pores or porins with new selectivities.

Publication types

  • Review

MeSH terms

  • Diffusion
  • Drug Design
  • Ion Channels
  • Membrane Proteins / chemistry*
  • Porins / chemistry*
  • Protein Folding
  • Protein Structure, Secondary
  • Voltage-Dependent Anion Channels

Substances

  • Ion Channels
  • Membrane Proteins
  • Porins
  • Voltage-Dependent Anion Channels