Replens versus dienoestrol cream in the symptomatic treatment of vaginal atrophy in postmenopausal women

Maturitas. 1996 Apr;23(3):259-63. doi: 10.1016/0378-5122(95)00955-8.


Objectives: This study was designed to evaluate the efficacy of Replens, a non-hormonal moisturizing vaginal gel, on symptoms of vaginal atrophy in postmenopausal women, in comparison with Dienoestrol (Cilag), an oestrogenic vaginal cream.

Methods: Thirty-nine patients were randomly allocated to either of the two treatments. Replens was given three times a week during the 12 weeks of the study, while Dienoestrol was administered daily during the first 2 weeks and thereafter three times a week. Vaginal dryness index, itching, irritation, dyspareunia, pH and safety were evaluated every week the first month and every month thereafter.

Results: Both treatments had a significant increase on vaginal dryness index as soon as the first week of treatment, and the hormonal compound was significantly better than the non-hormonal one. All symptoms such as itching, irritation and dyspareunia significantly decreased or disappeared without any difference between the two treatments. For pH, no significant difference was seen either in each group or between the two groups. No adverse events related with the two drugs were found.

Conclusion: This study shows that Replens applied vaginally three times a week, is a full therapy for all symptoms of vaginal atrophy as well as local estrogen. No serious adverse event was related. Replens is an alternative treatment to local estrogen and perhaps a good complement of systemic HRT in patient suffering from vaginal dryness.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Intravaginal
  • Atrophy / drug therapy
  • Dienestrol / administration & dosage*
  • Female
  • Humans
  • Lipids
  • Lubrication
  • Middle Aged
  • Postmenopause
  • Vagina / pathology*
  • Vaginal Creams, Foams, and Jellies / administration & dosage*
  • Vaginal Diseases / drug therapy*


  • Lipids
  • Replens
  • Vaginal Creams, Foams, and Jellies
  • Dienestrol