Multiple evanescent white dot syndrome after hepatitis B vaccine

Am J Ophthalmol. 1996 Sep;122(3):431-2. doi: 10.1016/s0002-9394(14)72074-4.


Purpose: Hepatitis B vaccine has become an effective means of preventing complications of hepatitis B. However, it occasionally induces serious side effects. We report a case of multiple evanescent white dot syndrome (MEWDS) that occurred following hepatitis B vaccination.

Methods: A 23-year-old woman with a one-week history of progressive loss of vision in the left eye and bilateral photopsia was referred for examination. Her symptoms appeared 24 hours after a booster intramuscular injection of hepatitis B vaccine.

Results: Clinical examination, fluorescein angiography, and the course of events were typical of MEWDS.

Conclusions: This case demonstrates the occasional occurrence of MEWDS after hepatitis B vaccine and suggests that hepatitis B virus immunization may be a risk factor for this retinal condition.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Hepatitis B / prevention & control
  • Hepatitis B Vaccines / adverse effects*
  • Humans
  • Retinal Diseases / etiology*
  • Retinal Diseases / physiopathology
  • Risk Factors
  • Vaccination / adverse effects*
  • Vision Disorders / etiology
  • Vision Disorders / physiopathology


  • Hepatitis B Vaccines