Abstract
The fungal pathogen Blastomyces dermatitidis produces an adhesin (WI-1) in yeast stages, which contains repetitive regions that bind host-cell receptors. Adhesin and glucan may modulate fungal interactions with macrophages; their level of expression is altered in hypovirulent mutants. Adhesin is also involved in immune responses, and may be important in eliciting the clearance of the fungus.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adhesins, Bacterial*
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Amino Acid Sequence
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Animals
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology
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Blastomyces / genetics
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Blastomyces / pathogenicity*
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Blastomyces / physiology
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Blastomycosis / etiology*
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Cell Membrane / physiology
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Fungal Proteins / genetics
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Fungal Proteins / immunology
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Fungal Proteins / physiology
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Glycoproteins / genetics
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Glycoproteins / immunology
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Glycoproteins / physiology
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Humans
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Models, Biological
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Molecular Sequence Data
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Virulence / physiology
Substances
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Adhesins, Bacterial
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Bacterial Proteins
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Fungal Proteins
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Glycoproteins
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invasin, Yersinia