Role of cell-surface molecules of Blastomyces dermatitidis in host-pathogen interactions

Trends Microbiol. 1996 Jun;4(6):246-51. doi: 10.1016/0966-842X(96)10028-7.

Abstract

The fungal pathogen Blastomyces dermatitidis produces an adhesin (WI-1) in yeast stages, which contains repetitive regions that bind host-cell receptors. Adhesin and glucan may modulate fungal interactions with macrophages; their level of expression is altered in hypovirulent mutants. Adhesin is also involved in immune responses, and may be important in eliciting the clearance of the fungus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adhesins, Bacterial*
  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology
  • Blastomyces / genetics
  • Blastomyces / pathogenicity*
  • Blastomyces / physiology
  • Blastomycosis / etiology*
  • Cell Membrane / physiology
  • Fungal Proteins / genetics
  • Fungal Proteins / immunology
  • Fungal Proteins / physiology
  • Glycoproteins / genetics
  • Glycoproteins / immunology
  • Glycoproteins / physiology
  • Humans
  • Models, Biological
  • Molecular Sequence Data
  • Virulence / physiology

Substances

  • Adhesins, Bacterial
  • Bacterial Proteins
  • Fungal Proteins
  • Glycoproteins
  • invasin, Yersinia