Monocyte Chemoattractant Protein 1: A Potential Regulator of Monocyte Recruitment in Inflammatory Disease

Mol Med Today. 1996 May;2(5):198-204. doi: 10.1016/1357-4310(96)88772-7.

Abstract

The appearance of specific types of leukocytes in inflammatory infiltrates may be governed by cell-specific chemoattractants called chemokines. In particular, monocyte chemoattractant protein 1 (MCP-1) has been implicated in diseases characterized by monocyte-rich infiltrates, including atherosclerosis, rheumatoid arthritis and multiple sclerosis. While we are beginning to understand the structural determinants that govern the activities of MCP-1 in vitro, we know much less about its physiological functions in vivo and its pathogenetic role in disease. However, recent data from genetically modified mice have begun to place MCP-1 in a central position in monocyte trafficking and activation.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemokine CCL2 / chemistry
  • Chemokine CCL2 / immunology*
  • Humans
  • Inflammation / immunology*
  • Mice
  • Molecular Sequence Data
  • Monocytes / immunology*
  • Structure-Activity Relationship

Substances

  • Chemokine CCL2