Isolated late asthmatic reaction after exposure to a high-molecular-weight occupational agent, subtilisin

Chest. 1996 Sep;110(3):823-4. doi: 10.1378/chest.110.3.823.


High-molecular-weight agents generally induce immediate asthmatic reactions. We report the case of a subject who experienced a reaction that started after the first hour following exposure to subtilisin, a high-molecular-weight occupational agent. Any occurrence of immediate reaction was ruled out by measuring both FEV1 and lung volumes every 10 min in the first hour. This reaction was IgE-mediated as shown by immediate skin reactivity and increased specific IgE levels.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asthma / chemically induced*
  • Asthma / physiopathology
  • Bronchial Provocation Tests
  • Forced Expiratory Volume
  • Health Personnel
  • Humans
  • Male
  • Molecular Weight
  • Occupational Diseases / chemically induced*
  • Occupational Diseases / physiopathology
  • Occupational Exposure*
  • Subtilisins / adverse effects*
  • Time Factors


  • Subtilisins