Immunogenetics of HTLV-I/II and associated diseases

J Acquir Immune Defic Syndr Hum Retrovirol. 1996:13 Suppl 1:S119-23. doi: 10.1097/00042560-199600001-00020.

Abstract

The ethnic background of human T-lymphotropic virus types I and II (HTLV-I/II) infections and associated diseases was investigated in association with human leukocyte antigens (HLA) (alleles) and haplotypes. Japanese HTLV-I carriers were characterized by two categories of HLA class I antigens (A24, A26, B7, B61, Cw1, and Cw7) and class II alleles (DRB1 *0101, 0803, 1403, 1501, and 1502 and DQB1 *0303, 0501, and 0601); one category was associated with adult T-cell leukemia (ATL) patients and the other with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. The ATL-associated haplotypes had unique DRB1-DQB1 alleles (0901-0303, 1501-0602, 1401-0503), which were correlated with a low immune responsiveness to HTLV-I, while the HAM/TSP haplotypes had different DRB1-DQB1 alleles (0101-0501, 0803-0601, 1502-0601), which were correlated with a high immune responsiveness to HTLV-I. Both ATL- and HAM/TSP-associated haplotypes were found among HTLV-I carriers and the patients from other ethnic groups (Jamaican blacks, Andes natives, South American mestizos, and Mashhadi Jews). HLA haplotypes of HTLV-II carriers were different from those of HTLV-I carriers among South American natives. These results suggested that HTLV-I/II infections and the associated diseases might be determined by immunogenetic factors segregated with HLA alleles and haplotypes.

Publication types

  • Review

MeSH terms

  • Carrier State
  • HTLV-I Infections / ethnology
  • HTLV-I Infections / genetics*
  • HTLV-I Infections / immunology
  • HTLV-II Infections / ethnology
  • HTLV-II Infections / genetics*
  • HTLV-II Infections / immunology
  • Haplotypes / genetics
  • Haplotypes / immunology
  • Histocompatibility Antigens Class I / analysis
  • Histocompatibility Antigens Class I / genetics
  • Histocompatibility Antigens Class I / immunology
  • Histocompatibility Antigens Class II / analysis
  • Histocompatibility Antigens Class II / genetics
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • Indians, North American / genetics
  • Jamaica
  • Japan
  • Jews / genetics
  • Leukemia, T-Cell / ethnology
  • Leukemia, T-Cell / genetics*
  • Paraparesis, Tropical Spastic / ethnology
  • Paraparesis, Tropical Spastic / genetics
  • South America

Substances

  • Histocompatibility Antigens Class I
  • Histocompatibility Antigens Class II