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, 86 (5), 777-86

The Product of par-4, a Gene Induced During Apoptosis, Interacts Selectively With the Atypical Isoforms of Protein Kinase C

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The Product of par-4, a Gene Induced During Apoptosis, Interacts Selectively With the Atypical Isoforms of Protein Kinase C

M T Díaz-Meco et al. Cell.

Abstract

The atypical PKCs are involved in a number of important cellular functions, including cell proliferation. We report here that the product of the par-4 gene specifically interacts with the regulatory domains of zeta PKC and lambda/LPKC, which dramatically inhibits their enzymatic activity. This is particularly challenging, because expression of par-4 has been shown to correlate with growth inhibition and apoptosis. Results are shown here demonstrating that the expression of par-4 in NIH-3T3 cells induces morphological changes typical of apoptosis, which are abrogated by cotransfection of either wild-type zeta PKC or lambda/LPKC, but not by their respective kinase-inactive mutants. These findings support a role for the atypical PKC subspecies in the control of cell growth and survival.

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