Connective tissue and joint disease in diabetes mellitus

Endocrinol Metab Clin North Am. 1996 Jun;25(2):473-83. doi: 10.1016/s0889-8529(05)70335-2.

Abstract

Connective tissue is ubiquitous and subject to alterations that result in changes in the extracellular matrix of vessels and tissues leading to the long-term complications of diabetes. This article reviews only those abnormalities of interstitial connective tissue involving skeleton, joints, skin, and periarticular tissues. Abnormalities in the skin and periarticular tissues result in syndromes limiting joint movement, including limited joint mobility, Dupuytren disease, flexor tenosynovitis, carpal tunnel syndrome, stiff-hand syndrome, and shoulder-hand reflex dystrophy. Of these, only limited joint mobility and stiff-hand syndrome occur exclusively in patients with diabetes. In all of these conditions, advanced glycation end products are thought to form as a result of nonenzymatic reaction of glucose with proteins, causing stiffening.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Bone Diseases / diagnosis
  • Bone Diseases / etiology*
  • Bone Diseases / physiopathology
  • Bone Diseases, Metabolic / diagnosis
  • Bone Diseases, Metabolic / etiology
  • Bone Diseases, Metabolic / physiopathology
  • Carpal Tunnel Syndrome / diagnosis
  • Carpal Tunnel Syndrome / etiology
  • Carpal Tunnel Syndrome / physiopathology
  • Child
  • Connective Tissue Diseases / diagnosis
  • Connective Tissue Diseases / etiology*
  • Diabetes Complications*
  • Diabetes Mellitus / physiopathology
  • Dupuytren Contracture / diagnosis
  • Dupuytren Contracture / etiology
  • Dupuytren Contracture / physiopathology
  • Female
  • Humans
  • Hyperostosis / diagnosis
  • Hyperostosis / etiology
  • Hyperostosis / physiopathology
  • Joint Diseases / diagnosis
  • Joint Diseases / etiology*
  • Joint Diseases / physiopathology
  • Male
  • Mixed Connective Tissue Disease / diagnosis
  • Mixed Connective Tissue Disease / etiology*
  • Mixed Connective Tissue Disease / physiopathology
  • Osteoarthritis / diagnosis
  • Osteoarthritis / etiology
  • Osteoarthritis / physiopathology
  • Osteolysis / diagnosis
  • Osteolysis / etiology
  • Osteolysis / physiopathology
  • Tenosynovitis / diagnosis
  • Tenosynovitis / etiology
  • Tenosynovitis / physiopathology