Efficacy of testosterone, trazodone and hypnotic suggestion in the treatment of non-organic male sexual dysfunction

Br J Urol. 1996 Feb;77(2):256-60. doi: 10.1046/j.1464-410x.1996.86316.x.


Objective: To examine the effects of hypnotic suggestions or the administration of testosterone or trazodone to impotent men with no detectable organic cause for the impotence.

Patients and methods: The study comprised 79 men in whom clinical and laboratory examinations revealed no organic cause for their impotence: 20 men (mean age 38.7 +/- 11.47 years) received testosterone, 21 men (mean age 39.5 +/- 10.73 years) received trazodone, 20 men (mean age 34.2 +/- 11.69 years) underwent hypnosis and 18 men (mean age 39.1 +/- 11.46 years) served as controls. They were assessed by interview 4, 6 and 8 weeks after starting treatment: the patient's reports were verified by interviewing their partners.

Results: Men who received a placebo had a 39% improvement in sexual function, while the rates of improvement in the treated groups were higher, but not significantly so. The success rates of testosterone and trazodone treatment and hypnotic suggestions were 60%, 67% and 80%, respectively.

Conclusion: Although the improvement was not statistically significant, treatment with testosterone and trazodone could be used as an adjuvant therapy in nonorganic male sexual dysfunction. The only treatment superior to placebo seemed to be hypnosis. A more effective treatment may be obtained by combining these therapeutic modalities, but this needs further study.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Erectile Dysfunction / therapy*
  • Humans
  • Hypnosis*
  • Libido
  • Male
  • Middle Aged
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Testosterone / therapeutic use*
  • Trazodone / therapeutic use*
  • Treatment Outcome


  • Serotonin Uptake Inhibitors
  • Testosterone
  • Trazodone