Thermoregulation and the pathogenesis of fever

Infect Dis Clin North Am. 1996 Jun;10(2):433-49. doi: 10.1016/s0891-5520(05)70306-8.


Infections, trauma, inflammatory processes, and some malignant diseases induce a constellation of host responses that are collectively referred to as the "acute-phase response." Elevation of core temperature is certainly part of the acute-phase response, and cytokines that raise core temperature in pathologic states are some of the same cytokines that account for other manifestations of the acute-phase response. This article examines fever as a part of the acute-phase reaction and the role of cytokines in thermoregulation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acute-Phase Reaction / etiology*
  • Analgesics, Non-Narcotic / pharmacology
  • Body Temperature Regulation*
  • C-Reactive Protein / analysis
  • Cytokines / genetics
  • Cytokines / physiology
  • Fever / drug therapy
  • Fever / etiology*
  • Humans
  • Hypothalamus / physiology
  • Infections / complications
  • Inflammation / complications
  • Neoplasms / complications
  • Pyrogens / physiology
  • Wounds and Injuries / complications


  • Analgesics, Non-Narcotic
  • Cytokines
  • Pyrogens
  • C-Reactive Protein