Amphotericin B resistant isolates of Cryptococcus neoformans without alteration in sterol biosynthesis

J Med Vet Mycol. Jun-Jul 1996;34(3):223-5.

Abstract

Amphotericin B resistant mutants of Cryptococcus neoformans were isolated accumulating mainly ergosterol. Cross-resistance to azole antifungals was not observed. Together with previous data this indicates that at least three categories of amphotericin B resistance can arise: sterol mutants, amphotericin B and azole cross-resistant mutants and amphotericin B resistant mutants with no azole cross-resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Cryptococcus neoformans / drug effects*
  • Cryptococcus neoformans / growth & development
  • Cryptococcus neoformans / metabolism*
  • Drug Resistance, Microbial
  • Sterols / biosynthesis*

Substances

  • Antifungal Agents
  • Sterols
  • Amphotericin B