Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 393 (1), 53-6

IL4 and IL13 Receptors Share the Gamma C Chain and Activate STAT6, STAT3 and STAT5 Proteins in Normal Human B Cells

Affiliations

IL4 and IL13 Receptors Share the Gamma C Chain and Activate STAT6, STAT3 and STAT5 Proteins in Normal Human B Cells

C Rolling et al. FEBS Lett.

Abstract

IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.

Similar articles

See all similar articles

Cited by 22 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback