The RING finger domain: a recent example of a sequence-structure family

Curr Opin Struct Biol. 1996 Jun;6(3):395-401. doi: 10.1016/s0959-440x(96)80060-1.


In the past 18 months, two RING finger structures have been solved. They represent the first reported structures for this novel zinc-binding sequence motif. Both structures are significantly different from other zinc-binding domains, in terms of both their zinc-ligation scheme and their three-dimensional structures. The RING finger domain appears to be a convenient scaffold which can be altered to provide functional specificity in those proteins that contain the motif.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Conformation*
  • Sequence Alignment*
  • Zinc Fingers*