Induction of macrophage antiprotozoal activity by monocyte chemotactic and activating factor

FEMS Immunol Med Microbiol. 1996 May;14(1):59-61. doi: 10.1111/j.1574-695X.1996.tb00268.x.

Abstract

To determine if monocyte chemotactic and activating factor (MCAF) induces intracellular antimicrobial activity, human monocyte-derived macrophages were treated with MCAF and challenged with Toxoplasma gondii and Leishmania donovani. Pretreatment with MCAF induced macrophages to inhibit protozoal replication by approximately 50%. These findings suggest a potential host defense role for MCAF in the inflammatory response to intracellular pathogens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chemokine CCL2 / pharmacology*
  • Humans
  • Leishmania donovani / drug effects*
  • Leishmania donovani / growth & development
  • Leishmaniasis / prevention & control*
  • Macrophages / parasitology*
  • Toxoplasma / drug effects*
  • Toxoplasma / growth & development
  • Toxoplasmosis / prevention & control*

Substances

  • Chemokine CCL2