Go outside and see the proteasome. Protein degradation

J M Lord

doi:10.1016/s0960-9822(02)70666-0

Go outside and see the proteasome. Protein degradation

Curr Biol. 1996 Sep 1;6(9):1067-9. doi: 10.1016/s0960-9822(02)70666-0.

Author

J M Lord¹

Affiliation

¹ Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.

PMID: 8805359
DOI: 10.1016/s0960-9822(02)70666-0

Abstract

Newly synthesized proteins that fail to fold or assemble properly in the endoplasmic reticulum are degraded. Recent work on several endoplasmic reticulum membrane proteins has shown that the cytosolic proteasome plays a role in their degradation.

Publication types

Review

MeSH terms

Cysteine Endopeptidases / metabolism*
Endoplasmic Reticulum / metabolism
Hydrolysis
Membrane Proteins / metabolism*
Multienzyme Complexes / metabolism*
Proteasome Endopeptidase Complex
Protein Folding

Substances

Membrane Proteins
Multienzyme Complexes
Cysteine Endopeptidases
Proteasome Endopeptidase Complex