Predicting the structure of protein complexes: a step in the right direction

B K Shoichet; I D Kuntz

doi:10.1016/s1074-5521(96)90256-2

Predicting the structure of protein complexes: a step in the right direction

Chem Biol. 1996 Mar;3(3):151-6. doi: 10.1016/s1074-5521(96)90256-2.

Authors

B K Shoichet¹, I D Kuntz

Affiliation

¹ Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, IL 60611-3008, USA.

PMID: 8807840
DOI: 10.1016/s1074-5521(96)90256-2

Abstract

In a blind test of protein-docking algorithms, six groups used different methods to predict the structure of a protein complex. All six predicted structures were close enough to the experimental complex to be useful; nevertheless, several important details of the experimental complex were missed or only partially predicted.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Algorithms
Models, Molecular
Protein Conformation*

Grants and funding

GM31497/GM/NIGMS NIH HHS/United States