Molecular mimicry in the MHC: hidden clues to autoimmunity?

Immunol Today. 1996 Feb;17(2):64-70. doi: 10.1016/0167-5699(96)80581-0.


The term 'molecular mimicry' has been used to describe a spectrum of antigenic crossreactivities thought to underlie autoimmune disease. For T-cell crossreactivities to occur, appropriate T-cell clones must be available. Here, Harold Baum, Huw Davies and Mark Peakman speculate that an important source of self-peptides that govern thymic selection of such clones are MHC molecules themselves.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoimmunity*
  • Cross Reactions
  • Histocompatibility Antigens*
  • Humans
  • Sequence Alignment
  • T-Lymphocytes / immunology


  • Histocompatibility Antigens