Expression of endothelin-1 immunoreactivity in breast cancer

Surg Oncol. 1995;4(6):309-15. doi: 10.1016/s0960-7404(10)80043-x.

Abstract

This study performed immunohistochemical staining for human ET-1, utilizing avidinbiotin-peroxidase complex detection to examine 47 surgically resected primary breast cancers. Positive immunoreactivity was demonstrated in 19 of the 47 breast cancers (40.4%). There was no significant relationship between the expression of ET-1 and clinicopathological findings. A significant difference was found between ET-1 positive and negative groups in the incidence of recurrence and distant metastasis (P < 0.05). The 5-year overall survival rate was significantly poorer in patients with ET-1-positive cancer (84.2%), compared to 96.4% in patients with ET-1 negative cancer (P < 0.01). The 5-year disease-free survival rate was significantly poorer in patients with ET-1-positive cancer (73.7%) compared to 96.4% in patients with ET-1-negative cancer (P < 0.05). These results suggest that the expression of ET-1 could be used as a possible indicator for predicting the metastatic potential of breast cancer.

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / immunology*
  • Breast Neoplasms / pathology*
  • Breast Neoplasms / surgery
  • Culture Techniques
  • Endothelin-1 / analysis*
  • Female
  • Humans
  • Immunohistochemistry / methods
  • Middle Aged
  • Prognosis
  • Reference Values
  • Sensitivity and Specificity
  • Survival Rate

Substances

  • Endothelin-1