IgA antigliadin antibodies as a screening method for nonovert celiac disease in children with insulin-dependent diabetes mellitus

J Pediatr Gastroenterol Nutr. 1996 Jul;23(1):29-33. doi: 10.1097/00005176-199607000-00006.


One hundred forty-one children with insulin-dependent diabetes mellitus were screened for serum immunoglobulin A (IgA) antigliadin antibodies by means of an enzyme-linked immunosorbent assay (ELISA) method. None of them had gastrointestinal symptoms, and no major nutritional disturbances were detected except for a girl with moderate growth delay. Twelve patients with positive IgA antigliadin antibodies on two or more consecutive measurements underwent a small intestinal biopsy; four of them had a subtotal villous atrophy, and celiac disease was diagnosed; in another patient, a partial villous atrophy was observed. Children suffering from both diabetes and celiac disease showed an onset of diabetes at a younger age than did nonceliac patients. Prevalence of celiac disease in the screened population is 2.85%, which is higher than in the general population of the Comunidad Valenciana (one in 2,500 live births).

MeSH terms

  • Adolescent
  • Biomarkers / blood
  • Celiac Disease / complications
  • Celiac Disease / diagnosis*
  • Celiac Disease / epidemiology
  • Child
  • Child, Preschool
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / complications*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gliadin / immunology*
  • Humans
  • Immunoglobulin A / blood*
  • Immunoglobulin A / immunology
  • Incidence
  • Male
  • Prevalence
  • Prospective Studies


  • Biomarkers
  • Immunoglobulin A
  • Gliadin