Diversity of OspA and OspC among cerebrospinal fluid isolates of Borrelia burgdorferi sensu lato from patients with neuroborreliosis in Germany

Med Microbiol Immunol. 1996 Feb;184(4):195-201. doi: 10.1007/BF02456135.


Neuroborreliosis is the most frequent manifestation of the second stage of Lyme borreliosis in Europe. However, only few isolates from the cerebrospinal fluid (CSF) have been characterized with controversial results. A large panel of 36 CSF isolates isolated over a 10-year period in Munich has now been analyzed for their OspA and OspC type, resulting in at least eight different types, respectively. Representatives of the different types cultivated from CSF in Munich have also been isolated from other geographical regions in Europe from CSF or ticks, suggesting a widespread distribution of pathogenic strains. A certain OspA type (type 4) was frequently observed in adults but rarely in children or ticks. Since OspA and OspC are the most promising candidates for a Borrelia vaccine, the considerable heterogeneity found among CSF isolates has important implications for development of a vaccine in Europe.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Antigens, Bacterial*
  • Antigens, Surface / cerebrospinal fluid
  • Antigens, Surface / genetics*
  • Bacterial Outer Membrane Proteins / cerebrospinal fluid
  • Bacterial Outer Membrane Proteins / genetics*
  • Bacterial Vaccines
  • Borrelia / classification
  • Borrelia / genetics*
  • Child
  • Child, Preschool
  • Cluster Analysis
  • Genetic Variation*
  • Germany / epidemiology
  • Humans
  • Lipoproteins*
  • Lyme Disease / cerebrospinal fluid
  • Lyme Disease / epidemiology
  • Lyme Disease / microbiology*
  • Middle Aged
  • Molecular Sequence Data
  • Serotyping


  • Antigens, Bacterial
  • Antigens, Surface
  • Bacterial Outer Membrane Proteins
  • Bacterial Vaccines
  • Lipoproteins
  • OspA protein
  • OspC protein

Associated data

  • GENBANK/X95353
  • GENBANK/X95354
  • GENBANK/X95355
  • GENBANK/X95356
  • GENBANK/X95357
  • GENBANK/X95358
  • GENBANK/X95360
  • GENBANK/X95361
  • GENBANK/X95362