Characteristics of the mouse genomic histamine H1 receptor gene

Genomics. 1996 Aug 15;36(1):178-81. doi: 10.1006/geno.1996.0441.

Abstract

We report here the molecular cloning of a mouse histamine H1 receptor gene. The protein deduced from the nucleotide sequence is composed of 488 amino acid residues with characteristic properties of GTP binding protein-coupled receptors. Our results suggest that the mouse histamine H1 receptor gene is a single locus, and no related sequences were detected. Interspecific backcross analysis indicated that the mouse histamine H1 receptor gene (Hrh1) is located in the central region of mouse Chromosome 6 linked to microphthalmia (Mitfmi), ras-related fibrosarcoma oncogene 1 (Raf1), and ret proto-oncogene (Ret) in a region of homology with human chromosome 3p.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromosome Mapping
  • Cloning, Molecular
  • Crosses, Genetic
  • GTP-Binding Proteins
  • Gene Dosage
  • Genes / genetics*
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data
  • Muridae
  • Polymorphism, Restriction Fragment Length
  • Receptors, Histamine H1 / genetics*
  • Sequence Homology, Amino Acid

Substances

  • Receptors, Histamine H1
  • GTP-Binding Proteins

Associated data

  • GENBANK/D50095