Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus

Genomics. 1996 Aug 1;35(3):473-85. doi: 10.1006/geno.1996.0387.


There are at least five murine Dlx genes that are related to the Drosophila Distal-less homeobox gene. The Dlx genes are primarily expressed in the developing forebrain, derivatives of the cranial neural crest and restricted epidermal craniofacial and limb domains. Dlx-2 is required for differentiation of subsets of cranial neural crest and forebrain cells. Previous genomic studies have shown that Dlx-1 and Dlx-2 are linked on mouse chromosome 2, near the HoxD cluster. Here we report a detailed analysis of the nucleotide sequence (approximately 14 kb), organization, and transcription of the murine Dlx-1 and Dlx-2 locus. In addition, we show that Dlx-1 makes multiple sense transcripts and at least one antisense transcript, whereas Dlx-2 makes one major transcript. The sequence of the human Dlx-2 gene is reported and is compared to that of the murine gene. Finally, sequence analysis of the deduced protein sequences reveals several candidate functional domains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary
  • Homeodomain Proteins / genetics*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Sequence Analysis, DNA*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Transcription Factors
  • Transcription, Genetic*


  • DNA, Complementary
  • Distal-less homeobox proteins
  • Homeodomain Proteins
  • Transcription Factors

Associated data

  • GENBANK/U51000
  • GENBANK/U51001
  • GENBANK/U51002
  • GENBANK/U51003