Low-frequency stimulation does not readily cause long-term depression or depotentiation in the dentate gyrus of awake rats

Brain Res. 1996 May 25;722(1-2):217-21. doi: 10.1016/0006-8993(96)00130-8.


The ability of low-frequency stimulation (LFS) to induce either long-term depression (LTD) or depotentiation was assessed for perforant path synapses in the dentate gyrus of awake, adult rats. Neither LFS at 1 Hz (100 or 900 pulses) nor LFS at 3 Hz (900 pulses) was sufficient to produce either LTD or depotentiation. LFS at 3 Hz did produce a transient response depression of previously potentiated synapses, but this lasted less than 24 h and was secondary to seizure-like afterdischarges. We conclude that the LFS protocols so effective at eliciting LTD and depotentiation in area CA1 are ineffective for perforant path synapses in the dentate gyrus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dentate Gyrus / physiology*
  • Electric Stimulation / methods
  • Electrophysiology
  • Long-Term Potentiation*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Seizures / physiopathology
  • Synapses / physiology
  • Time Factors