Low-frequency stimulation does not readily cause long-term depression or depotentiation in the dentate gyrus of awake rats

W C Abraham; S E Mason-Parker; B Logan

doi:10.1016/0006-8993(96)00130-8

Low-frequency stimulation does not readily cause long-term depression or depotentiation in the dentate gyrus of awake rats

Brain Res. 1996 May 25;722(1-2):217-21. doi: 10.1016/0006-8993(96)00130-8.

Authors

W C Abraham¹, S E Mason-Parker, B Logan

Affiliation

¹ Department of Psychology, University of Otago, Dunedin, New Zealand. cabraham@otago.ac.nz

PMID: 8813372
DOI: 10.1016/0006-8993(96)00130-8

Abstract

The ability of low-frequency stimulation (LFS) to induce either long-term depression (LTD) or depotentiation was assessed for perforant path synapses in the dentate gyrus of awake, adult rats. Neither LFS at 1 Hz (100 or 900 pulses) nor LFS at 3 Hz (900 pulses) was sufficient to produce either LTD or depotentiation. LFS at 3 Hz did produce a transient response depression of previously potentiated synapses, but this lasted less than 24 h and was secondary to seizure-like afterdischarges. We conclude that the LFS protocols so effective at eliciting LTD and depotentiation in area CA1 are ineffective for perforant path synapses in the dentate gyrus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dentate Gyrus / physiology*
Electric Stimulation / methods
Electrophysiology
Long-Term Potentiation*
Male
Rats
Rats, Sprague-Dawley
Seizures / physiopathology
Synapses / physiology
Time Factors