Transforming growth factor-beta 1 promotes re-elongation of injured axons of cultured rat hippocampal neurons

Brain Res. 1996 Jun 3;723(1-2):206-9. doi: 10.1016/0006-8993(96)00253-3.


Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following axotomy was investigated. The axonal growth was stopped by laser irradiation, but addition of TGF-beta 1 remarkably promoted the axonal re-elongation from the injured site. The effect of TGF-beta 1 was concentration dependent and seen maximally at a concentration of 1 ng/ml. These results suggest that TGF-beta 1 has a capability of promoting axonal regeneration of brain neurons after lesioning.

MeSH terms

  • Animals
  • Axons / drug effects*
  • Cells, Cultured / drug effects
  • Dose-Response Relationship, Drug
  • Hippocampus / drug effects*
  • Rats
  • Transforming Growth Factor beta / pharmacology*


  • Transforming Growth Factor beta