This research examined the influences of social circumstances, coping and level and length of drug intake on dependence and withdrawal from benzodiazepine use. A sample of long-term benzodiazepine users were followed up over a period of six months. At first interview the participants' drug intake and anxiety and depression levels were established and the Life Events and Difficulties Schedule (LEDS) was administered. At follow up these measures were repeated and individuals' coping strategies for dealing with dependence were also assessed. By the time of the follow-up interview slightly more than half of the participants (57 per cent) had either withdrawn completely from benzodiazepine medication or had reduced their daily dose. Analyses showed that reduction was unrelated to factors associated with the drugs themselves, to the severity of life-events and difficulties, to lessening of difficulties or to the occurrence of positive life-events. Significant associations, however, were found between participants' coping responses in relation to long-term benzodiazepine use and the individuals' reduction or cessation of benzodiazepine use in the six month study period. The study showed that in the absence of positive life-events and in spite of ongoing difficulties actively confronting the problems of benzodiazepine use can have a positive effect on outcome. The findings suggest that interventions which encourage cognitive, behavioural and affective aspects of coping are those which would appear to be most likely to succeed.