Antibodies to beta 2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus

Arthritis Rheum. 1996 Sep;39(9):1466-74. doi: 10.1002/art.1780390905.


Objective: To investigate whether anticardiolipin antibodies (aCL) in patients with systemic lupus erythematosus (SLE) bind to beta 2-glycoprotein I (beta 2GPI), and to search for a relationship between the presence of IgG and/or IgM anti-beta 2GPI antibody and clinical manifestations in SLE patients.

Methods: IgG and IgM anti-beta 2GPI in 308 Japanese SLE patients were measured using phospholipid-independent enzyme immunoassays. Relationships to clinical histories and to various laboratory data were examined.

Results: The values of anti-beta 2GPI and aCL, as measured by conventional enzyme immunoassay, showed a strong correlation, but the anti-beta 2GPI assay was more useful in distinguishing beta 2GPI-dependent aCL from beta 2GPI-independent aCL. The presence of IgG anti-beta 2GPI was associated with an increased frequency of a history of thrombosis. Comparisons of various laboratory data suggested that the titer of anti-beta 2GPI may fluctuate with disease activity.

Conclusion: The results suggest that pathogenic aCL is directed against structurally altered beta 2GPI and that enzyme immunoassay for anti-beta 2GPI may prove useful in evaluating the risk of thrombosis and monitoring the clinical course in patients with SLE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / immunology
  • Antibodies / blood*
  • Antibodies, Anticardiolipin / blood*
  • Female
  • Glycoproteins / immunology*
  • Humans
  • Immunoglobulin G / blood*
  • Immunoglobulin M / blood*
  • Lupus Coagulation Inhibitor / blood
  • Lupus Erythematosus, Systemic / blood
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / immunology*
  • Pregnancy
  • Retrospective Studies
  • Syphilis Serodiagnosis
  • Thrombosis / immunology*
  • beta 2-Glycoprotein I


  • Antibodies
  • Antibodies, Anticardiolipin
  • Glycoproteins
  • Immunoglobulin G
  • Immunoglobulin M
  • Lupus Coagulation Inhibitor
  • beta 2-Glycoprotein I