Treatment of psoriatic arthritis with extracorporeal photochemotherapy and conventional psoralen-ultraviolet A irradiation

Arthritis Rheum. 1996 Sep;39(9):1519-23. doi: 10.1002/art.1780390911.


Objective: To study the use of combined photopheresis and psoralen-ultraviolet A irradiation (PUVA) in the treatment of psoriatic arthritis.

Methods: Eight patients with psoriasis and sero-negative arthritis received photopheresis for 12 weeks, followed by photopheresis plus PUVA for another 12 weeks. Clinical and laboratory examinations were performed every 3 months for up to 1 year after therapy.

Results: Four patients experienced a marked improvement of joint symptoms that lasted for > or = 12 months post-therapy (74% decrease in the Ritchie articular index; P < 0.01). Prior to therapy, these patients had a higher CD4:CD8 ratio than the poor responders. Only minor laboratory changes occurred.

Conclusion: A more extensive trial of photopheresis plus PUVA in psoriatic arthritis is warranted.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthritis, Psoriatic / blood
  • Arthritis, Psoriatic / complications
  • Arthritis, Psoriatic / drug therapy*
  • CD4-CD8 Ratio
  • Female
  • Humans
  • Male
  • Middle Aged
  • PUVA Therapy*
  • Photopheresis
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome