Physiology and biochemistry of the kidney vacuolar H+-ATPase

Annu Rev Physiol. 1996;58:427-45. doi: 10.1146/


Vacuolar H+-ATPases have an essential role in renal hydrogen ion secretion in the proximal tubule, collecting duct, and other segments of the nephron. Control of H+ transport is achieved by variations in the intrinsic properties of the renal H+-ATPases and by several cellular regulatory mechanisms, including redistribution of the enzyme both by vesicular traffic and regulated assembly and disassembly, and cytosolic regulatory proteins that interact directly with H+-ATPase. These mechanisms may provide a means for fine control of net acid excretion and for regulating vacuolar H+-ATPases residing on the plasma membrane independently from those in intracellular compartments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Kidney / enzymology*
  • Kidney / ultrastructure
  • Proton-Translocating ATPases / metabolism*
  • Vacuoles / enzymology
  • Vacuoles / ultrastructure


  • Proton-Translocating ATPases