Clinical significance of serum concentration of interleukin 8 in patients with bronchial asthma or chronic pulmonary emphysema

Respiration. 1996;63(4):236-40. doi: 10.1159/000196552.


Interleukin-8 (IL-8) belongs to the family of chemotactic cytokines and has been shown to activate neutrophils in vitro and in vivo. In this study, we measured IL-8 concentration in the serum of patients with pulmonary emphysema or bronchial asthma. IL-8 concentration in serum of emphysema patients was significantly higher than in asthmatics; in emphysema patients it was significantly correlated with the smoking index and the annual decrease of FEV1.0. In asthmatics IL-8 concentration was below the level of detection, but was markedly increased during exacerbation of asthma. Our findings suggest that IL-8 may be one of the causal factors in these diseases.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Asthma / blood*
  • Asthma / physiopathology
  • Chronic Disease
  • Female
  • Forced Expiratory Volume
  • Humans
  • Interleukin-8 / blood*
  • Male
  • Middle Aged
  • Osmolar Concentration
  • Pulmonary Emphysema / blood*
  • Pulmonary Emphysema / physiopathology


  • Interleukin-8