Epidemiology of cryptococcosis in France: a 9-year survey (1985-1993). French Cryptococcosis Study Group

Clin Infect Dis. 1996 Jul;23(1):82-90. doi: 10.1093/clinids/23.1.82.


We analyzed the data collected during a nationwide survey of cryptococcosis (1985-1993). We first checked the quality of the survey. The stability of its completeness (approximately 50%) and its representativity were assessed by the capture-recapture method after we cross-checked our data on cryptococcosis (as a presenting manifestation of AIDS) against those of the national registry of AIDS. Of the 1,057 cases of cryptococcosis (1,013 patients), 827 (86%) involved patients with AIDS. The increasing number of cases of human immunodeficiency virus (HIV)-related cryptococcosis over time paralleled the AIDS epidemic except for a higher male-to-female ratio. Malignancies (32%), organ transplantation (19%), and corticosteroid therapy (33%) were the main predisposing conditions in 163 patients without AIDS. Cryptococcal meningitis more frequently occurred in patients with AIDS than in HIV-negative patients (P < 10(-6)). Among the 413 isolates available for serotyping, 410 were Cryptococcus neoformans variety neoformans (including 20.5% of serotype D). Three isolates of the variety gattii (serotype B) were recovered from patients without AIDS.

MeSH terms

  • AIDS-Related Opportunistic Infections / complications
  • AIDS-Related Opportunistic Infections / epidemiology
  • AIDS-Related Opportunistic Infections / microbiology
  • Adolescent
  • Adult
  • Aged
  • Antifungal Agents / therapeutic use
  • Child
  • Cryptococcosis / complications
  • Cryptococcosis / epidemiology*
  • Cryptococcosis / microbiology
  • Cryptococcus neoformans / classification
  • Cryptococcus neoformans / isolation & purification
  • Data Collection
  • Evaluation Studies as Topic
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Serotyping
  • Surveys and Questionnaires
  • Time Factors


  • Antifungal Agents