Participation of the autonomic nervous system in lipolysis induced by intraventricular injection of carbachol in the pigeon

J Auton Nerv Syst. 1996 Jun 10;59(1-2):83-6. doi: 10.1016/0165-1838(96)00006-9.

Abstract

The possible involvement of central cholinergic neurotransmission in lipomobilization in avian species was investigated by injecting carbachol into the brain lateral ventricle (i.c.v.) of conscious pigeons (N = 9 per experimental group). I.c.v. injections of carbachol (27 nmol in 1 microliter) induced an intense increase (nearly 91% above baseline levels) in the concentration of plasma free fatty acids (FFA). Previous intraperitoneal administration of hexamethonium (10 mg/kg) completely blocked the lipomobilizing effect of i.c.v. injections of carbachol. These results suggest that cholinergic neurons may be involved in central mechanisms controlling FFA mobilization in pigeons, and that this response is mainly mediated by activation of autonomic nervous system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / metabolism
  • Animals
  • Autonomic Nervous System / physiology*
  • Carbachol / administration & dosage
  • Carbachol / pharmacology*
  • Cholinergic Agonists / administration & dosage
  • Cholinergic Agonists / pharmacology*
  • Cholinergic Antagonists / pharmacology
  • Columbidae / metabolism*
  • Fatty Acids, Nonesterified / blood
  • Female
  • Hexamethonium / pharmacology
  • Injections, Intraventricular
  • Lipolysis / drug effects
  • Lipolysis / physiology*
  • Male
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology

Substances

  • Cholinergic Agonists
  • Cholinergic Antagonists
  • Fatty Acids, Nonesterified
  • Hexamethonium
  • Carbachol
  • Acetylcholine