Activity-dependent beta-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region

Neuron. 1996 Sep;17(3):475-82. doi: 10.1016/s0896-6273(00)80179-8.


beta-Adrenergic receptor activation has a central role in the enhancement of memory formation that occurs during heightened states of emotional arousal. Although beta-adrenergic receptor activation may enhance memory formation by modulating long-term potentiation (LTP), a candidate synaptic mechanism involved in memory formation, the cellular basis of this modulation is not fully understood. Here, we report that, in the CA1 region of the hippocampus, beta-adrenergic receptor activation selectively enables the induction of LTP during long trains of 5 Hz synaptic stimulation. Protein phosphatase inhibitors mimic the effects of beta-adrenergic receptor activation on 5 Hz stimulation-induced LTP, suggesting that activation of noradrenergic systems during emotional arousal may enhance memory formation by inhibiting protein phosphatases that normally oppose the induction of LTP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Electric Stimulation
  • Electrophysiology
  • Hippocampus / chemistry
  • Hippocampus / cytology
  • Hippocampus / physiology*
  • Long-Term Potentiation / physiology*
  • Mice
  • Mice, Inbred C57BL
  • Pyramidal Cells / physiology
  • Receptors, Adrenergic, beta / physiology*


  • Receptors, Adrenergic, beta