Frequent deletion of chromosome 1p sequences in an aggressive histologic subtype of endometrial cancer

Hum Mol Genet. 1996 Jul;5(7):1017-21. doi: 10.1093/hmg/5.7.1017.


The molecular genetic events underlying endometrial tumorigenesis are ill-defined at present. We have identified a region on the short arm of chromosome 1 which is frequently deleted in endometrial cancers. The region of deletion has been localized to bands 1p32-33. Deletion of 1p32-33 is seen more frequently in cancers of the highly aggressive papillary serous type than in cancers of the less-aggressive endometrioid type. These data suggest the presence of a tumor suppressor gene on 1p32-33 which is specifically involved in the development of endometrial cancers with poor outcome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma, Clear Cell / genetics
  • Carcinoma, Endometrioid / genetics
  • Chromosome Deletion*
  • Chromosomes, Human / genetics
  • Chromosomes, Human, Pair 1 / genetics*
  • Cystadenocarcinoma, Papillary / genetics*
  • Endometrial Neoplasms / genetics*
  • Female
  • Genetic Markers
  • Heterozygote
  • Humans
  • Microsatellite Repeats
  • Polymorphism, Genetic


  • Genetic Markers