Antisense oligodeoxynucleotides to c-fos are amnestic for passive avoidance in the chick

Neuroreport. 1996 May 17;7(7):1269-72. doi: 10.1097/00001756-199605170-00010.


Induction of c-fos occurs in the forebrain when chicks are trained on a passive avoidance task. Suppression of c-Fos protein synthesis with antisense oligodeoxynucleotides prevented long-term memory retention when injected 10-11 h before training, but not if injections were made between 3 h pre-and 3 h post-training. c-fos expression is thus necessary for long-term memory retention, presumably because of its control of induction of the signalling pathway that ultimately results in the protein synthesis subserving synaptic remodelling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amnesia / chemically induced*
  • Animals
  • Avoidance Learning / drug effects*
  • Chickens
  • Female
  • Male
  • Molecular Sequence Data
  • Oligonucleotides, Antisense / pharmacology*
  • Proto-Oncogene Proteins c-fos / biosynthesis*
  • Retention, Psychology / drug effects*


  • Oligonucleotides, Antisense
  • Proto-Oncogene Proteins c-fos